Watch the recording now: Elucidating the mechanism of small molecule induced protein degradation
08 March 2021
Thursday, March 25th, 2021 - 8.00 am PST / 11.00 am EST / 3.00 pm GMT / 4.00 pm CET
Elucidating the mechanism of small molecule induced protein degradation
The mystery of BI-3802’s BCL6 induced protein degradation is finally solved! The unique mode of action was recently published in Nature1 and received a lot of publicity. Watch our joined seminar, where Mikołaj Słabicki, Hojong Yoon, and Jonas Koeppel from Dana-Farber Cancer Institute and Manfred Koegl and Steffen Steurer from Boehringer Ingelheim present and discuss the details of BI-3802’s mechanism.
Subscribe to our newsletter to stay updated on our regular additions to opnMe.com.
About our BCL6 Degrader BI-3802:
BCL6 degrader BI-3802 is a single digit nanomolar BCL6::Co-repressor inhibitor which induces efficacious BCL6 protein degradation and represents ideal in vitro probe compound for testing hypotheses around BCL6 biology. The molecule is made available on opnMe.com free of charge to foster independent innovation of scientific groups.
About opnMe:
opnMe.com, the new open innovation portal of Boehringer Ingelheim, aims to accelerate research initiatives to enable new insights of disease biology in areas of high unmet medical need by sharing well-characterized molecules and offer collaborations for science. In the spirit of collaboration, our molecules are provided to the scientific community to help unlock and fulfil their full potential. These molecules are either freely available as “Molecules to Order” or applied via scientific research submissions as “Molecules for Collaboration”. As part of our third pillar, our “opn2EXPERTS” program, we also enlist scientific advice on key biologic issues to fuel further drug discovery and deliver novel solutions that benefit unmet patient needs.
1Small-molecule-induced polymerization triggers degradation of BCL6 Słabicki M., Yoon H., Koeppel J., Nitsch L., Roy Burman S. S., Di Genua C., Donovan K. A., Sperling A. S., Hunkeler M., Tsai J. M., Sharma R., Guirguis A., Zou C., Chudasama P., Gasser J. A., Miller P. G., Scholl C., Fröhling S., Nowak R. P., Fischer E. S., Ebert B. L. Nature 2020, 588, 164–168.