Publications

General literature

DOI

Boehringer Ingelheim experiments with open-access chemical probes

A. Mullard Boehringer Ingelheim experiments with open-access chemical probes, Nature Reviews Drug Discovery 2018, 17, 7.

Molecule specific literature

Epigenetic target
DOI
PUBMED

BET PROTAC ǀ MZ 1

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4

Michael Zengerle, Kwok-Ho Chan, and Alessio Ciulli

ACS Chem Biol. 2015, 10, 1770–1777.

Epigenetic target
DOI
PUBMED

BET PROTAC ǀ MZ 1

Structural basis of PROTAC cooperative recognition for selective protein degradation

Morgan S Gadd, Andrea Testa, Xavier Lucas, Kwok-Ho Chan, Wenzhang Chen, Douglas J Lamont, Michael Zengerle and Alessio Ciulli

Nat. Chem. Biol. 2017, 13, 514–521.

Epigenetic target
DOI
PUBMED

BET PROTAC ǀ MZ 1

Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds

Kwok-Ho Chan, Michael Zengerle, Andrea Testa, and Alessio Ciulli

J. Med. Chem. 2018, 61, 504-513.