Ordering FAQs (Molecules to order)

How does ordering work and what has been the success of the program so far?

Ordering a molecule on opnMe is easy; just watch the below video.

What is the timeframe between order and shipment of the requested molecule?

The compound will normally be shipped within 2 weeks of an order being placed.

Will the molecules be shipped free of charge?

Yes, all molecules that can be ordered on opnMe.com (Molecules to order) will be shipped free of charge. This means we cover the costs of synthesis and shipping up to your bench. For shipments outside of Europe, we have to provide a pro-forma value for our molecules to meet international customs regulations. The value of 2,16 €/mg is declared for customs purpose only. Please note that local custom fees may apply and we advise you to check with your local authorities. In case of questions, please contact us for further information.

How much molecule can I order?

5 mg of molecule compound, in solid form, will be shipped. On occasion, we may be able to supply larger quantities of compound upon special request and a discussion of the intended research plan.

How to dissolve the opnMe molecules when they arrived at my laboratory?

All our compounds available on opnMe.com are soluble in pure DMSO @ 10mM, and can be stored in solution for several months @ -4°C to -20°C. This solution can be used for your dilutions in your different assays. Please, keep in mind that the remaining quantity of DMSO in your assays depends on the dilution scheme you have used! For storage you can refrigerate our molecules as a solid stock @ 4°C for months without any risk of degradation.

What is the meaning of the 2-or 3-letters code written on my molecule vial?

The 2-or-3 letters code refer to the salt that was used to purify our molecules as part of the last step of their synthesis. It means that you will read on the vial a molecular weight slightly different from the one you can find on opnMe.com. In order to understand which exact salt has been used, please refer to the salt code on the molecule vial and the table below. The table provides you also with the information regarding how much the salt changes the molecular weight.

Salt Code	Salt	Description	Molecular Weight g/mol or Da
BS	Free Base	No salt defined The molecule is a base	-
XX	No salt defined	No salt defined	-
CL2	Dihydrochloride	Salt formed with two hydrochloric acid molecules	72.9
LML	L-Malate	Salt formed with L-Malic acid or (S)-Hydroxybutanedioic acid	134.0
MU	N-Methyl-D-glucamine	Salt formed with N-Methyl-D-glucamine (Meglumine)	195.2
NA	Sodium	Sodium salt	22.9
PH	Phosphate	Salt with phosphoric acid	97.9
TF	Trifluoracetic acid	Salt with trifluoracetic acid	114.0
SE	acid	No salt defined; indicates acid character of the molecule	-
FO	Formiate	Salt with Formic acid	46.0

Are the molecules’ pharmacological profile and structure available?

These compounds are released with a comprehensive data package describing potency on designated target, selectivity information versus other targets and pharmacokinetic characterization. The structure is available on the ordering page.

How are the molecules requested?

Molecules to order are normally released upon request without review or a research plan.

Is funding available to support preclinical proof-of-concept studies with these compounds?

These compounds are provided free of charge without additional funding to support experiments.

Will other external scientists be able to see my order?

No. All orders are handled internally by Boehringer Ingelheim.

Who owns any potential IP arising from novel experimental observations?

In this case, Boehringer Ingelheim simply provides access to the characterized tool compounds and you are free to use them as experimental tools to probe biological mechanisms and, if appropriate, make new claims for therapeutic utility – all arising IP belongs to you.

Are the molecules suitable for in vivo proof-of-concept studies?

These tool compounds are highly characterized with respect to potency, selectivity and pharmacokinetics. They are suitable for in vivo preclinical studies and guidelines are available to advise on species previously tested, dose selection, dose regimen and formulation.

Have the molecules completed preclinical safety assessment?

No. We aim to make unique tool compounds available at a very early stage as the biology is evolving; hence, the compounds will not have been subject to a comprehensive safety evaluation. They are provided as experimental tools for in vitro and in vivo studies and should be treated appropriately according to the practices within your institute.

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